Ipamorelin explained: sequence, CAS number and formats

Ipamorelin is a synthetic pentapeptide, a chain of five residues with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂. It is classed as a growth hormone secretagogue receptor (GHS-R) ligand and is described in the literature as notably selective within that class. This guide covers its identifiers, what is unusual about its sequence, and the listings that contain it.

Ipamorelin at a glance

What is unusual about the Ipamorelin sequence?

Most of its residues are not among the twenty standard amino acids found in natural proteins.

• Aib is aminoisobutyric acid, a non-standard amino acid.
• D-2-Nal is D-2-naphthylalanine, a synthetic residue.
• D-Phe is the D-form (mirror image) of phenylalanine.
• NH₂ at the end indicates that the C-terminus is an amide rather than a free acid.

Only histidine and lysine appear in their standard form. This makes Ipamorelin a fully synthetic design rather than a fragment of a natural protein, and it means the full sequence, including the terminal amide, is what defines the compound.

How does Ipamorelin differ from CJC-1295?

They are different compounds from different classes. The two are often listed together, but neither is a form of the other.

See CJC-1295 No DAC and Modified GRF (1-29) for the second compound.

Which listings contain Ipamorelin?

The difference between the blend and the duo is explained in peptide blends vs separate vials.

What should the documentation show?

• The compound name and batch number match the vial label.
• An HPLC purity figure and an identity result.
• The salt form tested, where stated. Ipamorelin Acetate is a listed synonym.

Batch documents are on the COAs page. See also how to read a peptide certificate of analysis.

Frequently asked questions

What is Ipamorelin?

Ipamorelin is a synthetic pentapeptide classed as a growth hormone secretagogue receptor (GHS-R) ligand.

What is the CAS number for Ipamorelin?

The CAS number for Ipamorelin is 170851-70-4.

What is the sequence of Ipamorelin?

Aib-His-D-2-Nal-D-Phe-Lys-NH2, a five-residue sequence with a C-terminal amide.

Is Ipamorelin the same as CJC-1295?

No. Ipamorelin is a five-residue GHS-R ligand. CJC-1295 without DAC is a 29-amino-acid GHRH analogue. They are different compounds with different CAS numbers.

What does NNC 26-0161 refer to?

NNC 26-0161 is a code used in the literature for Ipamorelin.

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The Ascend Research team