Tesamorelin vs Sermorelin: identifiers compared
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Tesamorelin and Sermorelin are both synthetic analogues related to growth hormone releasing hormone (GHRH), but they are different compounds: Tesamorelin has 44 amino acids and an N-terminal modification, while Sermorelin is the unmodified first 29 amino acids. This guide sets them side by side, with Modified GRF (1-29) as a third reference point, so each can be identified from its documentation.
The three compounds at a glance
| Tesamorelin | Sermorelin | CJC-1295 (No DAC) | |
|---|---|---|---|
| Length | 44 amino acids | 29 amino acids | 29 amino acids |
| CAS number | 218949-48-5 | 86168-78-7 | 863288-34-0 |
| Also called | Tesamorelin Acetate, TH9507 | GHRH(1-29), Sermorelin Acetate | Modified GRF (1-29) |
| Modification | N-terminal trans-3-hexenoyl group | None (reference sequence) | Four amino acid substitutions |
What is Sermorelin?
Sermorelin is a synthetic peptide corresponding to the first 29 amino acids of human GHRH. It is the unmodified GHRH(1-29) sequence, and in the literature it serves as the reference against which analogues are compared.
What is Tesamorelin?
Tesamorelin is a synthetic 44-amino-acid analogue of human growth hormone releasing factor. Its distinguishing feature is a trans-3-hexenoyl group attached at the N-terminus, a modification made for stability. It is longer than Sermorelin and chemically modified, so the two have different masses.
Where does Modified GRF (1-29) fit?
Modified GRF (1-29), also called CJC-1295 without DAC, is the same length as Sermorelin but carries four amino acid substitutions. It is covered in CJC-1295 No DAC and Modified GRF (1-29).
How can you tell them apart on a certificate of analysis?
- CAS number. Each compound has its own, listed in the table above.
- Mass. A 44-residue peptide and a 29-residue peptide have clearly different expected masses, and the substituted 29-residue analogue differs again from the unmodified one.
- Name and batch. The certificate should name the compound exactly as the vial label does, with a matching batch number.
See how to read a peptide certificate of analysis for more on these checks.
How are they supplied by Ascend Research?
| Listing | Format |
|---|---|
| Tesamorelin 10mg | One vial, white lyophilised powder |
| Sermorelin 10mg | One vial, white lyophilised powder |
| CJC-1295 (No DAC) 10mg | One vial, white lyophilised powder |
All three are grouped under the research peptide series and dispatched from within Australia. Batch documents are on the COAs page.
Frequently asked questions
What is the difference between Tesamorelin and Sermorelin?
Tesamorelin is a 44-amino-acid analogue with an N-terminal trans-3-hexenoyl group. Sermorelin is the unmodified first 29 amino acids of GHRH. They have different CAS numbers and different masses.
What is the CAS number for Tesamorelin?
The CAS number for Tesamorelin is 218949-48-5.
What is the CAS number for Sermorelin?
The CAS number for Sermorelin is 86168-78-7.
How many amino acids are in Tesamorelin and Sermorelin?
Tesamorelin has 44 amino acids. Sermorelin has 29.
Is Sermorelin the same as Modified GRF (1-29)?
No. Both are 29 amino acids long, but Modified GRF (1-29) carries four amino acid substitutions relative to the Sermorelin sequence.
All Ascend Research products are sold strictly for laboratory research use only. They are not for human or animal use, and nothing in this article is medical advice.
The Ascend Research team
